DLX5

DLX5
DLX5

DLX5
Struktur des DLX5-Proteins

Das Homöobox-Protein DLX-5 ist ein Protein, für welches das bei Menschen vorhandene DLX5-Gen codiert.[1][2]

Das Gen ist den Drosophila-„Distal-less”-Genen (DLX) sehr ähnlich. Die „Distal-less” (Dlx)-Genfamilie umfasst mindestens sechs verschiedene Elemente, DLX1–DLX6. Das codierte Protein hat eine Funktion bei der Knochenentwicklung und bei Frakturheilungen. Mutationen in dem Gen, das in einer Konfiguration mit anderen Vertretern der Genfamilie auf dem langen Arm von Chromosom 7 vorkommt, können mit einer Fehlbildung („split-hand/split-foot“) verbunden sein.[2]

Interaktion

DLX2 wies Protein-Protein-Interaktionen bei DLX2,[3] MSX1[3] und Msh homeobox 2 auf.[3]

Einzelnachweise

  1. ↑ Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al.: Cloning and characterization of two members of the vertebrate Dlx gene family. In: Proc Natl Acad Sci U S A. 91, Nr. 6, April 1994, S. 2250–4. doi:10.1073/pnas.91.6.2250. PMID 7907794. Volltext bei PMC: 43348.
  2. ↑ a b Entrez Gene: DLX5 distal-less homeobox 5. Abgerufen am 28. Oktober 2011.
  3. ↑ a b c H Zhang, Hu G, Wang H, Sciavolino P, Iler N, Shen M M, Abate-Shen C: Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. In: Mol. Cell. Biol.. 17, Nr. 5, UNITED STATES, May. 1997, S. 2920–32. PMID 9111364. Volltext bei PMC: 232144.

Literatur

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  • Scherer SW, Poorkaj P, Massa H, et al.: Physical mapping of the split hand/split foot locus on chromosome 7 and implication in syndromic ectrodactyly.. In: Hum. Mol. Genet.. 3, Nr. 8, 1995, S. 1345–54. doi:10.1093/hmg/3.8.1345. PMID 7987313.
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  • Zhang H, Hu G, Wang H, et al.: Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism.. In: Mol. Cell. Biol.. 17, Nr. 5, 1997, S. 2920–32. PMID 9111364. Volltext bei PMC: 232144.
  • Newberry EP, Latifi T, Towler DA: The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter.. In: Biochemistry. 38, Nr. 33, 1999, S. 10678–90. doi:10.1021/bi990967j. PMID 10451362.
  • Eisenstat DD, Liu JK, Mione M, et al.: DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation.. In: J. Comp. Neurol.. 414, Nr. 2, 1999, S. 217–37. doi:10.1002/(SICI)1096-9861(19991115)414:2<217::AID-CNE6>3.0.CO;2-I. PMID 10516593.
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