NOD SCID

NOD SCID

Nod SCID bezeichnet ein Mausmodell, das in der biologischen Forschung – insbesondere in der Krebs- und Diabetesforschung – breite Anwendung findet.

In diesem Modell wird die SCID-Mutation (engl. Severe Combined Immunodeficiency, schwerer kombinierter Immundefekt) mit einem NOD (engl. Non-Obese Diabetic, Nicht-fettleibig-diabetisch)-Typ kombiniert. Bei Tieren, die homozygot für die SCID-Mutation sind, bilden sich keine funktionellen T-Zellen oder B-Zellen. Durch diesen Immundefekt sind diese Tiere hervorragend geeignet um körperfremde Zellen, z. B. transplantierte Tumore oder T-Zellen, zu tolerieren.

Durch den NOD-Hintergrund eignen sich diese Tiere auch sehr gut für die Untersuchung von Diabetes mellitus Typ I.


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