CDK-Inhibitor 1

CDK-Inhibitor 1
CDK-Inhibitor 1

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Masse/Länge Primärstruktur 163 Aminosäuren
Bezeichner
Gen-Name CDKN1A
Externe IDs OMIM: 116899 UniProt: P38936
Vorkommen
Übergeordnetes Taxon Säugetiere[1]

Der CDK-Inhibitor 1 (auch: p21) ist ein Inhibitor cyclin-abhängiger Kinasen (Cyclin dependent kinase), der wesentlich für die Kontrolle des Zellzyklus in Säugetieren ist. p21 unterdrückt unter anderem das Krebswachstum.

Das für p21 kodierende Gen liegt beim Menschen auf Chromosom 6 Genlocus p21.2. p21 wird von Zellen hauptsächlich auf der Transkriptionsebene reguliert. Eine Induktion der Transkription des p21 führt zu einem Stillstand des Zellzyklus, während eine Hemmung der Transkription zu verschiedenen Effekten führt, die vom Kontext abhängen.[2] p21-Knockout-Mäuse entwickeln sich normal bis zum Alter von etwa 16 Monaten. Dann beginnen sie, Tumore zu entwickeln.

Referenzen

  1. ↑ Homologe bei OMA
  2. ↑ Gartel AL und Radhakrishnan SK: Lost in Transcription: p21 Repression, Mechanisms, and Consequences. In: Cancer Research 65, 2005, S. 3980-3985. [1]

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