Signal Recognition Particle

Signal Recognition Particle
signal recognition particle 9kDa

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Bezeichner
Gen-Name SRP9
Externe IDs OMIM: 600707 UniProt: P49458
signal recognition particle 14kDa

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Bezeichner
Gen-Name SRP14
Externe IDs OMIM: 600708 UniProt: P37108
signal recognition particle 19kDa

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Bezeichner
Gen-Name SRP19
Externe IDs OMIM: 182175 UniProt: P09132
signal recognition particle 54kDa

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Bezeichner
Gen-Name SRP54
Externe IDs OMIM: 604857 UniProt: P61011
signal recognition particle 68kDa

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Bezeichner
Gen-Name SRP68
Externe IDs OMIM: 604858 UniProt: Q9UHB9
signal recognition particle 72kDa

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Bezeichner
Gen-Name SRP72
Externe IDs OMIM: 602122 UniProt: O76094

Das Signalerkennungs-Partikel (engl.: Signal Recognition Particle), ist ein Ribonukleoprotein-Komplex, der am Transport von Proteinen in das endoplasmatische Retikulum von Eukaryoten und die Plasmamembran von Prokaryoten beteiligt ist.

Der Kern des SRP ist universell und in allen drei biologischen Reichen konserviert.

Der SRP-Komplex in Eukaryoten besteht aus 6 Polypeptiden und einer 7SL-RNA. Der Komplex besitzt GTPase-Aktivität. Die Erkennung des Signalpeptids, welches im Zentrum aus mindestens 8 unpolaren Aminosäuren besteht, erfolgt im GTP-gebundenen Zustand.[1]

Der SRP-Komplex liegt in Eukaryoten im Cytosol vor. Er bindet reversibel an die Signalsequenz eines gerade translatierten Proteins und an die große Untereinheit des Ribosoms. Die Translation des Proteins wird unterbrochen und der gesamte Polypeptid-SRP-Ribosom-Komplex bindet an einen SRP-Rezeptor des endoplasmatischen Reticulums. Über einen Translokationsapparat wird die bereits vorliegende Aminosäurekette in das Lumen des endoplasmatischen Reticulums verbracht. Das SRP und dessen Rezeptor hydrolysieren währenddessen GTP zu GDP, und dissoziieren fort. Die Translation wird daraufhin fortgesetzt.

Inhaltsverzeichnis

Komponenten

Geschichte

Das SRP wurde von Peter Walter identifiziert und charakterisiert, als er als Aufbaustudent unter Günter Blobel arbeitete.[2]

Einzelnachweise

  1. ↑ [1]
  2. ↑ [2]

Weblinks


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