Osteonectin

Osteonectin
Osteonectin

Osteonectin
Bändermodell eines verkürzten Osteonectin-Trimers (Aminosäuren 71-303), nach PDB 1BMO
Masse/Länge Primärstruktur 286 Aminosäuren
Kofaktor Ca2+
Bezeichner
Gen-Name SPARC
Externe IDs OMIM: 182120 UniProt: P09486
Vorkommen
Übergeordnetes Taxon mehrzellige Tiere[1]

Osteonectin (SPARC) (von engl. Secreted protein acidic and rich in cysteine) ist ein Glykoprotein, das von Tierzellen sekretiert wird. Es wird in der extrazellulären Matrix in nahezu allen Geweben während Umbau- und Entwicklungsvorgängen sowie Krankheiten exprimiert. Es ist in der Lage, mehrere Calcium-Ionen aufzunehmen und bindet an nahezu alle Matrixproteine, Wachstumsfaktoren, Serumalbumin und an Zellen. Es reguliert Zell-Matrix-Wechselwirkungen und moduliert Zellwanderungen (Zellmigration).

Literatur

Thomas Kreis, Ronald Vale: Guidebook to the extracellular matrix, anchor, and adhesion proteins. Oxford University Press, 2. Afl. 1999, ISBN 9780198599586, S. 480.

Einzelnachweise

  1. ↑ Orthologe bei OMA

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