Carboxypeptidase

Carboxypeptidase
Carboxypeptidasen

Enzymklassifikation
EC, Kategorie 3.4.16  Hydrolase
Substrat Peptide und Proteine

Carboxypeptidasen sind Enzyme, die hydrolytische Spaltungen von Peptidbindungen vom C-terminalen Ende aus katalysieren. Deshalb sind sie Exopeptidasen.

Zwei namensgebende Vertreter dieser Gruppe sind die Carboxypeptidase A (EC 3.4.17.1, CAS 11075-17-5) und die Carboxypeptidase B (EC 3.4.17.2, CAS 9025-24-5). Beide sind Metalloproteine, die aus ihren Vorstufen (Procarboxypeptidasen) durch Trypsin mittels limitierter Proteolyse entstehen und Proteine endständig angreifen (Exopeptidasen). Sie werden vom exokrinen Pankreas sezerniert.

Die Carboxypeptidase A spaltet nach neutralen und zum Teil nach sauren Aminosäuren. Die Carboxypeptidase B spaltet nach basischen Aminosäuren. Die Carboxypeptidase G2 wirkt bei einer Methotrexat-Vergiftung als Antidot durch Abspaltung des Glutaminsäurerestes.


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  • Carboxypeptidase — (EC number 3.4.16 3.4.18) is an enzyme that hydrolyzes the carboxy terminal (C terminal) end of a peptide bond. Humans, animals, and plants contain several types of carboxypeptidases with diverse functions ranging from catabolism to protein… …   Wikipedia

  • Carboxypeptidase B2 — (plasma) Rendering based on PDB 3D66 …   Wikipedia

  • Carboxypeptidase A2 — (pancreatic), also known as CPA2, is a human gene.cite web | title = Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1358| accessdate = ] PBB Summary… …   Wikipedia

  • Carboxypeptidase A — usually refers to the pancreatic exopeptidase which hydrolyzes peptide bonds of C terminal residues with aromatic or aliphatic side chains. Most scientists in the field now refer to this enzyme as Gene|CPA1, and to a related pancreatic… …   Wikipedia

  • Carboxypeptidase B — protein Name=carboxypeptidase B1 (tissue) caption= width= HGNCid=2299 Symbol=CPB1 AltSymbols= EntrezGene=1360 OMIM=114852 RefSeq=NM 001871 UniProt=P15086 PDB= ECnumber=3.4.17.2 Chromosome=3 Arm=q Band=24 LocusSupplementaryData=protein… …   Wikipedia

  • carboxypeptidase — Enzymes (particularly of pancreas) that remove the C terminal amino acid from a protein or peptide. Carboxypeptidase A, (EC 3.4.17.1) will remove any amino acid; carboxypeptidase B (EC 3.4.17.2) is specific for terminal lysine or arginine …   Dictionary of molecular biology

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  • carboxypeptidase — noun Date: 1935 an enzyme that hydrolyzes peptides and especially polypeptides by splitting off sequentially the amino acids at the end of the peptide chain which contain free carboxyl groups …   New Collegiate Dictionary

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