Lead time bias

Lead time bias

Beim lead time bias handelt es sich um einen Fehler (engl. bias, Verzerrung), der bei Studien zur Krebsfrüherkennung eine Rolle spielt. Er beschreibt eine nur scheinbar verlängerte Überlebenszeit bei Vorverlegung des Diagnosezeitpunkts verglichen mit Patienten, die erst nach klinischen Symptomen eine Diagnose gestellt bekommen. Steht keine wirksame Therapie zur Verfügung, ist die Wirkung des entsprechenden Screenings nicht relevant – das heißt, die Diagnose wird früher gestellt, und der Patient lebt nach Diagnosestellung länger, insgesamt besteht jedoch kein Gewinn an Lebenszeit durch Durchführung des Screenings.

Andere wichtige Fehlermöglichkeiten in medizinischen Studien sind confounder, selection bias, missclassification bias.


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