Low Density Lipoprotein Receptor-related Protein 1
- Low Density Lipoprotein Receptor-related Protein 1
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Das Low Density Lipoprotein Receptor-related Protein 1 (LRP1) ist ein zellulärer Membranrezeptor der LDL-Rezeptorfamilie. Er ist ein Dimer aus einem 85 kDa schweren Transmembranfragment und einem auf der extrazellulären Seite nicht-kovalent verbundenen, 515 kDa schweren Fragment.
LRP1 ist ein Multiligandenrezeptor, der zunächst als Transportrezeptor entdeckt wurde, mittlerweile jedoch auch als Signalrezeptor beschrieben wurde [1].
Eine der Funktionen von LRP1 ist die Apolipoprotein-E-vermittelte Aufnahme von Chylomikronen-Remnants in die Leber[2].
Quellen
- ↑ Herz J, Strcikland DK: LRP: a multifunctional scavenger and signaling receptor. (2001) J Clin Invest 108 (6):779-84. PMID 11560943
- ↑ Beisiegel U, Weber W, Ihrke G, Herz J, Stanley KK: The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. (1989) Nature 341 (6238):162-4. PMID 2779654
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