Phosphatidylinositol-4,5-bisphosphate
- Phosphatidylinositol-4,5-bisphosphate
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Die Phosphatidylinositol-4,5-bisphosphate (Abk. PIP2) sind eine Gruppe von Phospholipiden, die nahezu ausschließlich in der dem Zellinneren zugewandten Seite der Zellmembran auftreten.
Sie spielen eine wichtige Rolle in der Weiterleitung extrazellulärer Signale in der Zelle. Durch Aktivierung bestimmter Rezeptoren, die sich in der Zellmembran befinden, kommt es zur Aktivierung des Enzyms Phospholipase C. Die Phospholipase C spaltet PIP2 durch Hydrolyse in Diacylglycerine (DAG) und Inositol-1,4,5-trisphosphat (IP3). Beide Produkte dieser Spaltung können als sogenannte Second Messenger zur Weiterleitung des Signals in der Zelle beitragen.
Phosphoinositid-3-Kinasen (PI3K) hingegen konvertieren PIP2 in Phosphatidylinositol-3,4,5-triphosphat (PIP3). Die umgekehrte Reaktion von PIP3 zu PIP2 erfolgt durch die Phosphatase PTEN.
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Phosphatidylinositol (3,5)-bisphosphate — (PtdIns(3,5) P 2) is a minor phospholipid component of cell membranes, yet important in distinguishing cell compartments. The generation of PtdIns(3,5) P 2 in internal membranes by the lipid kinase PIKfyve recruits a number of important proteins… … Wikipedia
Phosphatidylinositol (3,4)-bisphosphate — (PtdIns(3,4) P 2) is a minor phospholipid component of cell membranes, yet an important second messenger. The generation of PtdIns(3,4) P 2 at the plasma membrane activates a number of important cell signaling pathways. PtdIns(3,4) P 2 is… … Wikipedia
Phosphatidylinositol (4,5)-bisphosphate — chembox new ImageFile = Phosphatidylinositol 4,5 bisphosphate.jpg OtherNames = Formula = C47H85O19P3 PubChem = 5497157 MolarMass= 1047.09 CASNo = 245126 95 8 Density= MeltingPt= BoilingPt=Phosphatidylinositol (4,5) bisphosphate (PtdIns(4,5) P 2)… … Wikipedia
Phosphatidylinositol-3,4-bisphosphate 4-phosphatase — In enzymology, a phosphatidylinositol 3,4 bisphosphate 4 phosphatase (EC number|3.1.3.66) is an enzyme that catalyzes the chemical reaction:1 phosphatidyl myo inositol 3,4 bisphosphate + H2O ightleftharpoons 1 phosphatidyl 1D myo inositol 3… … Wikipedia
Phosphatidylinositol-4,5-bisphosphate 3-kinase — In enzymology, a phosphatidylinositol 4,5 bisphosphate 3 kinase (EC number|2.7.1.153) is an enzyme that catalyzes the chemical reaction:ATP + 1 phosphatidyl 1D myo inositol 4,5 bisphosphate ightleftharpoons ADP + 1 phosphatidyl 1D myo inositol… … Wikipedia
Phosphatidylinositol — (abbreviated PtdIns, or PI) is a minor phospholipid component in the cytosolic side of eukaryotic cell membranes. Being an amphiphile, this molecule possesses polymorphic behaviour, that is currently a topic of research in academic study.… … Wikipedia
Phosphatidylinositol bisphosphate — may refer to: * Phosphatidylinositol (3,4) bisphosphate * Phosphatidylinositol (3,5) bisphosphate * Phosphatidylinositol (4,5) bisphosphate … Wikipedia
Phosphatidylinositol (3,4,5)-trisphosphate — (PtdIns(3,4,5) P 3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3 kinases (PI 3 kinases) activity on phosphatidylinositol (4,5) bisphosphate. PtdIns(3,4,5) P 3 is dephophosphorylated by the phosphatase, PTEN on the … Wikipedia
Phosphatidylinositol 4-phosphate — (PtdIns4 P ) is a precursor of Phosphatidylinositol (4,5) bisphosphate. PtdIns4 P is prevalent in the membrane of the Golgi apparatus.In the Golgi apparatus, PtdIns4 P binds to the GTP binding protein ARF and to effector proteins, including four… … Wikipedia
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase — In enzymology, a phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase (EC number|3.1.3.67) is an enzyme that catalyzes the chemical reaction:phosphatidylinositol 3,4,5 trisphosphate + H2O ightleftharpoons phosphatidylinositol 4,5 bisphosphate + … Wikipedia
Strukturformel von PIP2, R steht für die Fettsäurereste Capryl, Oleyl, Palmityl, Arachidonyl oder Stearyl.
Wikibooks: Inositolphosphat-Stoffwechsel – Lern- und Lehrmaterialien
